Chemotherapy Toxicity

Chemotherapy is very effective and the standard treatment for patients with cancer. Generally, chemotherapy drugs act on cells that move through the cell cycle, including normal cells of hair follicles, bone marrow, gastrointestinal mucosa, ovary, testis and cancer cells. It determines the side effects that occurred with chemotherapy, such as hair loss, diarrhea, mouth sores and low blood counts.


Most patients with toxicity of chemotherapy, it is strongly linked proteinaceous drugs.
Chemotherapy drugs can affect normal cells or processes including DNA and RNA synthesis, cell division and many other chemical reactions inside the cell. Patients with highly protein bound chemotherapy drugs such as celecoxib, amlodipine and omeprazole with chemotherapy drugs may experience hematologic side effects such as low white blood cells. Patients may experience non-hematological chemotherapy unpleasant effects such as diarrhea and fatigue, medications that reduce cytochrome P450 enzyme as ketoconazable and amiodarone.

Radiotherapy and adjuvant chemotherapy give excellent performance in breast cancer. However, both can damage normal tissues and shape affect the quality of life. This effect on normal cells due to causes apoptosis of normal cells.

Ectopic over expression of anti-apoptotic Bcl-2 molecule can reduce the chemotherapy and radiotherapy-induced apoptosis of normal cells and contributes to reducing the toxicity of chemotherapy and radiotherapy.

Chemotherapy drugs can also lead to skin toxicity. It rashes, such as alopecia is hair loss, rash extremities, recall responses, skin necrosis, photosensitivity, acneiform reutions, nail changes, neutrophilic eccrine hidradenitis, mucositis, hyperpigmentation, sclerotic skin reactions, vascular lesions, xerosis and other reactions.

Note the palm of skin redness of the hands and soles.